Here is a scratchpad on some of the things our research has found may cause or contribute to small fiber peripheral neuropathy, and some potential treatment options. Do you have any additions or thoughts?
– SFN can be caused by a Vitamin B12 vitamin deficiency, meaning not enough B12 in the blood.
– SFN can be caused by a Vitamin B6 vitamin excess, meaning way too much B6 in the blood.
The testing currently being done is to figure out what portion of your cells are being affected – the nerves themselves or the myelin sheath. And how severe is the damage? Is it idiopathic, sensory or autonomic? Possible specific neuropathies to be tested for include Chronic Inflammatory Demyelinating Polyneuropathy where your immune system is attacking the sheaths.
Two additional tests that can be done are spinal taps and QSARTs.
In terms of treatment, there are many options as there doesn’t seem to be one set of solid pathways currently spelled out. In no particular order:
IVIg (very expensive though)
Zostrix HP (cream)
Cayenne Powder Capsules
There was promise with a “new morphine” pain killer called ABT-594 but they stopped human trials due to unacceptable gastroenteral side effects.